A brief history of the science and ethics of antipsychotics of off-label prescribing -- Pharmacoepidemiology of antipsychotic use in Canadian children and adolescents -- Do we know if they work and if they are safe : second-generation antipsychotics for treatment of autism spectrum disorders and disruptive behavior disorders in children and adolescents -- Ensuring the safety of children treated with second-generation antipsychotics -- Pediatric clinical trial activity for antipsychotics and the sharing of results : a complex ethical landscape -- Pathways to overmedication and polypharmacy : case examples from adolescents with fetal alcohol spectrum disorders -- Implementing change in prescribing practices -- Canadian initiatives and recommendations : safeguarding the health of children and youth receiving off-label treatment with antipsychotics. --From publisher description.