Unravelling mechanisms underlying ischaemic arrhythmias - the importance of models
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Peer Reviewed
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Author (aut): Guppy, Leon J.
Author (aut): Walker, M.J.
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| Abstract |
Abstract
A new model of regional ischaemia using blood-perfused isolated rat hearts is reported in this issue. This model has potential value in pharmacology to test the actions of drugs against the arrhythmias that arise early period (0-30 min) after induction of ischaemia. Unfortunately, the severity of arrhythmias in this new model is reduced, when compared to other models, in both the early and the late period (1-4 h) of coronary artery occlusion. This commentary compares the new model with previous models, and comments on the possible mechanisms of arrhythmias induced by ischaemia.
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Publication Number
Volume 137, Issue 7
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DOI
10.1038/sj.bjp.0704976
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ISSN
0007-1188
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| Use and Reproduction |
Use and Reproduction
©2002. British Journal of Pharmacology. Wiley (British Pharmacological Society).
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Rights Statement
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| Keywords |
Keywords
Arrhythmias
ischaemia models
blood perfused
ischaemia
isolated hearts
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