Nerve growth factor and striatal gluthathione metabolism in a rat model of Huntington's disease

Summary

Collection(s)	Collection(s) DC Faculty Research & Scholarship
Content type	Content type Digital Document
Resource Type	Resource Type Text
Genre	Genre article
Language	Language English
Peer Review Status	Peer Review Status Peer Reviewed

Persons and Affiliations

Persons	Author (aut): Cruz-Aguado, Reyniel Author (aut): Turner, Liliana F. Author (aut): Dı́az, Carmen M. Author (aut): Piñero, Janet

Abstract/Description

Abstract	Abstract Examined the influence of nerve growth factor (NGF) on striatal glutathione (GSH) content and the activities of GSH-related enzymes from quinolinic acid (QA)-lesioned rats. 75 rats were intrastriatally injected with QA and NGF. Enzymatic and GSH assays were performed 1 week later. NGF prevented the QA-induced decline in glutathione reductase activity and GSH content. It is concluded that NGF is able to prevent some of the disturbances induced by the excitotoxic insult in the striatal GSH metabolism. <p> Purpose: To test the influence of nerve growth factor (NGF) on striatal glutathione (GSH) content and the activities of GSH-related enzymes from quinolinic acid-lesioned rats. <p>Methods: Rats were intrastriatally injected with QA and NGF. Enzymatic and GSH assays were performed one week later. <p>Results: NGF prevented the QA-induced decline in glutathione reductase activity and GSH content. <p>Conclusions: NGF is able to prevent some of the disturbances induced by the excitotoxic insult in the striatal GSH metabolism.

Abstract

Examined the influence of nerve growth factor (NGF) on striatal glutathione (GSH) content and the activities of GSH-related enzymes from quinolinic acid (QA)-lesioned rats. 75 rats were intrastriatally injected with QA and NGF. Enzymatic and GSH assays were performed 1 week later. NGF prevented the QA-induced decline in glutathione reductase activity and GSH content. It is concluded that NGF is able to prevent some of the disturbances induced by the excitotoxic insult in the striatal GSH metabolism. <p> Purpose: To test the influence of nerve growth factor (NGF) on striatal glutathione (GSH) content and the activities of GSH-related enzymes from quinolinic acid-lesioned rats. <p>Methods: Rats were intrastriatally injected with QA and NGF. Enzymatic and GSH assays were performed one week later. <p>Results: NGF prevented the QA-induced decline in glutathione reductase activity and GSH content. <p>Conclusions: NGF is able to prevent some of the disturbances induced by the excitotoxic insult in the striatal GSH metabolism.

Publication/Container Information

Publication Title	Publication Title Restorative Neurology and Neuroscience
Publication Number	Publication Number Volume 17, Issue 4

Identifiers

ISSN	ISSN 0922-6028

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URL	URL https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip%2Csso&db=psyh&A…
Use and Reproduction	Use and Reproduction ©2001. Restorative Neurology and Neuroscience. IOS Press.
Rights Statement	Rights Statement IN COPYRIGHT - EDUCATIONAL USE PERMITTED

Subjects and Classifications

Keywords	Keywords nerve growth factor striatum Oxidative stress Huntington's disease quinolinic acid glutathione

Nerve growth factor and striatal gluthathione metabolism in a rat model of Huntington's disease

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